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Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)

Dr Swapnil Pawar July 26, 2022 35


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    Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)
    Dr Swapnil Pawar

SJS/TEN Shownotes

 

Written by Dr Andrew Lam

 

SJS – Skin detachment affecting <10% of body surface area

TEN – Skin detachment affecting >30% of body surface area

SJS/TEN Overlap Syndrome – Skin detachment affecting 10-30% of body surface area

 

SJS/TEN vs. DRESS vs. AGEP

 

SJS/TEN DRESS AGEP
Time till Onset of Rash 1-3 Weeks 2-6 Weeks 48 Hours
Cutaneous Features Confluent macular erythema, bullae, mucocutaneous features Facial oedema, morbiliform eruption, exfoliative dermatitis Pinpoint pustules with underlying erythematous base
Histological Features Epidermal Necrosis Perivascular lymphocytosis Subcorneal pustules
Mortality 5-35% 10% 5%

 

Causes of SJS

 

Drugs

  • Allopurinol
  • Sulfonamide antibiotics
  • Anti-epileptics
  • NSAID’s

 

Infection

  • Mycoplasma Pneumonia (particularly in children)

 

Idiopathic

 

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