
Serotonin Syndrome
play_arrow Serotonin Syndrome Dr Swapnil Pawar Serotonin Syndrome Written by Dr Andrew Lam Hunter Criteria: The presence of a serotonergic agent in addition to one of the following: Spontaneous […]
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DVT
Deep vein thrombosis is a venous thromboembolism found in the deep veins of the body, typically in the lower extremities. They are associated with life-threatening complications such as pulmonary embolism. In NSW hospitals, there has been a movement towards reducing the incidence of hospital-related VTE with the VTE prophylaxis assessment tool
Superficial vein thrombosis is generally benign and a self-limiting disorder. However, if axial veins are involved, there is a potential to propagate into the deep vein system as well.
Risk factors
Modifiable | Non-modifiable |
Immobilisation for prolonged periods of time
Surgery (especially orthopaedic surgeries) Trauma Drugs (COCP, HRT, etc) Pregnancy (including 6 weeks post partum) |
Inherited thrombophilia (Factor V Leiden, Protein C and S deficiency, Antithrombin deficiency)
Antiphospholipid syndrome Malignancy |
Anatomy
Deep veins of the lower extremity
Superficial veins of the lower extremity
Management
Management depends on the patient’s risk of bleeding and the location of the DVT. Typically patients are definitively treated with therapeutic anticoagulation, thrombolytic therapy or an IVC filter.
Anticoagulation is the definitive therapy for the proximal and distal DVTs in patients whose bleeding risk is acceptable. Typically, treatment duration is for 3-6 months following commencement of anticoagulation. This is dependent on Haematology advice for consideration of follow-up and assessment of whether this incident is provoked or unprovoked, which would require further thrombophilia workup.
However, in patients with a high risk of bleeding and a lower risk of embolisation, serial surveillance of compressive ultrasounds may be considered acceptable. If there is a high risk of embolisation in patients with contraindications to anticoagulant therapy, an IVC filter would be considered.
Anticoagulation Options
Drugs | Dosage for VTE treatment | Considerations |
Clexane SC | 1mg/kg twice daily OR
1.5mg/kg daily |
Contraindicated in renal impairment |
Heparin IV | As per VTE protocol, aiming for APTT 70-90s | Will require intravenous access and frequent blood test monitoring
Appropriate for patients who are peri-operative or require bridging |
Apixaban | 10mg twice daily for 7 days, then 5mg twice daily | Dose adjustment for renal impairment, age and weight |
Rivaroxaban | 15mg twice daily for 3 weeks, then 20mg daily | Dose adjustment for renal impairment, age and weight |
Dabigatran | Parenteral anticoagulation for 5-10 days, then 150mg twice daily | Contraindicated/dose adjusted in renal impairment
Has reversal agent (Idarucizumab) |
Warfarin | Will need to be bridged until the dose is adjusted to aim INR 2-3 | Adherence may be affected by frequent monitoring
Can be used in patients with renal impairment |
References
UpToDate “Overview of the treatment of proximal and distal lower extremity deep vein thrombosis (DVT)”
UpToDate “Direct oral anticoagulants (DOACs) and parenteral direct-acting anticoagulants: Dosing and adverse effects”
Dr Swapnil Pawar February 11, 2024
play_arrow Serotonin Syndrome Dr Swapnil Pawar Serotonin Syndrome Written by Dr Andrew Lam Hunter Criteria: The presence of a serotonergic agent in addition to one of the following: Spontaneous […]
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