
Gout
play_arrow Gout Dr Swapnil Pawar Written by – Dr Andrew Lam Gout vs. Pseudogout Gout Pseudogout Predominant Sites Affected Small Joints (i.e. 1st MTP) Large Joints (i.e. knee) Clinical Findings […]
Rhabdomyolysis Dr Swapnil Pawar
LOVIT trial – Final Nail in the Coffin for Vit C in Septic Shock? Dr Swapnil Pawar
Medspresso #Episode 51: Asthma Dr Swapnil Pawar
ICU Primary: Bedside Preparation – Renal Physiology Dr Swapnil Pawar
Paracetamol Overdose
Dr Swapnil Pawar
Clinical Stages of Paracetamol Overdose
Stage I (0-24 hours) – relatively non-specific with nausea, vomiting, malaise and diaphoresis, though some patients may be asymptomatic. Uncommonly may have CNS depression
Stage II (24-72 hours) – resolution of initial Stage I symptoms with subsequent development of RUQ pain and hepatic enlargement. Uptrending LFT’s.
Stage III (72-96 hours) – Peak LFT derangement with manifestations of liver failure (jaundice, hepatic encephalopathy, coagulopathy). Most people who die from their overdose will die in this stage from multi-organ failure
Stage IV (Days 4-7) – Symptoms resolve and patients recover, usually by day 7. Those who have had large overdoses or who were severely ill may have more protracted recoveries past a week
Paracetamol Overdose Normogram
N.B. If the patient has ingested a toxic dose of paracetamol (>10g) and presents >8 hours post-ingestion, commence NAC infusion before paracetamol level returns.
NAC Regimens
Standard NAC Infusion:
200mg/kg of NAC in 500ml’s over 4 hours, and then the 2nd bag with 100mg/kg in 1L over 16 hours
Higher Dose NAC Infusion:
200mg/kg of NAC in 500ml’s over 4 hours, and the 2nd bag contains 200mg/kg in 1L over 16 hours
Extended NAC Infusion
100mg/kg of NAC in 1L over 16 hours
Dr Swapnil Pawar November 8, 2021
play_arrow Gout Dr Swapnil Pawar Written by – Dr Andrew Lam Gout vs. Pseudogout Gout Pseudogout Predominant Sites Affected Small Joints (i.e. 1st MTP) Large Joints (i.e. knee) Clinical Findings […]
Dr Swapnil Pawar July 4, 2022
Dr Swapnil Pawar June 21, 2022
©Allrights reserved. Get Your Web Site Designed By St.George Web Design. Get a quote on your web design.