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Pharmacology

12 Results / Page 1 on 2


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eCritCare Podcast
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VITAMINS Trial

Dr Swapnil Pawar February 13, 2020

Sir William Osler said that “except on a few occasions, the patient appears to die from the body’s response to infection rather than from the infection” Sepsis is a major problem across the globe. Apart from the enormous financial costs of sepsis, the human toll of this disease is staggering […]

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PEPTIC Study

Dr Swapnil Pawar January 29, 2020

Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation Design This was a multi-centre cluster randomised trial involving 50 ICUs in Australia, New Zealand, Canada, Ireland, and the UK.  The units were randomised (as opposed to […]

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Thrombolysis in Submassive PE

Dr Swapnil Pawar December 31, 2019

The role of thrombolysis in submassive PE remains controversial to date. In this podcast, Dr Chacko & I dive deeper to explore the current evidence on this topic. What is Submassive PE and what are the key differences between Submissive and Massive PE The terms massive, submassive, and low-risk PE […]

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ESETT Trial

Dr Swapnil Pawar December 8, 2019

Status epilepticus poses a significant challenge to intensive care physicians. There is lots of uncertainty about the treatment options and correct dosing. In this podcast, we discuss the landmark ESETT trial published in NEJM which explores this dilemma but rather helping us to solve the problem, this trial asks more […]

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Stress Ulcer Prophylaxis in ICU

Dr Swapnil Pawar November 17, 2019

Dr Jose Chacko & Dr Swapnil Pawar Stress-induced gastrointestinal ulcers are common among patients admitted to the intensive care unit (ICU). These ulcers impose significant morbidity and mortality, therefore, stress ulcer prophylaxis (SUP) is a common clinical practice among healthcare providers dealing with these critically-ill patients.  A survey of 58 […]

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CRASH 3 – A Fairy Tale of Victory of Tranexamic acid & Dr Utako Okamoto

Dr Swapnil Pawar October 26, 2019

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial Intro –  As we know, TRANEXAMIC ACID is a synthetic analogue of the amino acid Lysine. It reduces bleeding by preventing the breakdown of fibrin […]

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Antibiotics

Augmented Renal Clearance in ICU

Dr Swapnil Pawar October 5, 2019

Dr Swapnil Pawar & Dr Jose Chacko What is ARC? Augmented renal clearance (ARC) is the phenomenon of enhanced renal function in critically ill patients. ARC is characterized by a higher than predicted increase in the renal elimination of solutes. It occurs due to an increase in glomerular filtration and […]

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Pharmacology

ICU Journal Club – VICCSS Study

Dr Swapnil Pawar September 1, 2019

Dr Swapnil Pawar & Dr Jose Chacko A Pilot, Randomised, Double-Blind Study of Vitamin C in the treatment of Vasoplegic Shock after Cardiac Surgery https://doi.org/10.1053/j.jvca.2019.08.034 Background-  High dose vitamin C has a strong biological rationale in post-cardiac surgery vasoplegia. Vitamin C scavenges reactive oxygen species, which likely contribute to vasoplegia […]