Evidence

play_arrow SWITCH Trial Dr Swapnil Pawar   Decompressive craniectomy plus best medical treatment versus best medical treatment alone for spontaneous severe deep supratentorial intracerebral hemorrhage: a randomized controlled clinical trial Beck J, Fung C, Strbian D, et al. Decompressive craniectomy plus best medical treatment versus best medical treatment alone for […]

play_arrow NICO Trial – Intubation in Acute Drug Overdose – Does Intubation Matter? Dr Swapnil Pawar   Blog Written by Dr Jose Chacko  Effect of Noninvasive Airway Management of Comatose Patients with Acute Poisoning: A Randomized Clinical Trial (Freund et al. JAMA. 2023;330(23):2267-2274. doi:10.1001/jama.2023.24391) Clinical question Assessment of the neurological […]

play_arrow PACER Trial Dr Swapnil Pawar Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia (the PACER trial) Van Baarle FLF, Van De Weerdt EK, Van Der Velden WJFM, Ruiterkamp RA, Tuinman PR, Ypma PF, et al. Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia. N Engl J Med. […]

play_arrow Oxygen Therapy in Intensive Care Dr Swapnil Pawar In our landmark 100th episode, we discuss the controversy around one of the most commonly used drugs in intensive care, i.e. Oxygen. In this episode, we dive deeper into the available evidence and recommend our approach for using oxygen in critically […]

play_arrow LOVIT trial – Final Nail in the Coffin for Vit C in Septic Shock? Dr Swapnil Pawar Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit Blog Written by Dr Jose Chacko Setting   Thirty-five medical–surgical ICUs in Canada, France, and New Zealand.   Included: Adult […]

play_arrow ICU Journal Club – CONTROLING Study Dr Swapnil Pawar Individualised versus conventional glucose control in critically ill patients: the CONTROLING study—a randomized clinical trial Blog written by Dr Jose Chacko Background –  Hyperglycaemia is an adaptive response to stress and is commonly seen in critically ill patients. Individualising hyperglycaemia […]

play_arrow Stopping Nasogastric feeds in ICU – Time for a CHANGE Dr Swapnil Pawar Malnutrition in critically ill patients in the intensive care unit (ICU) has been associated with increased infectious morbidity, increased length of ICU and hospital stay, increased rate of infections, increased number of ventilator days, and impaired […]

play_arrow Monoclonal Antibodies in COVID-19 Dr Swapnil Pawar Monoclonal Antibodies in COVID-19 Blog Written by – Dr Jose Chacko The COVID-19 pandemic continues to rage unabated in many parts of the world. India is by far the worst affected, with uncontrolled transmission across the country. Mutant variants have been implicated […]

play_arrow Thromboprophylaxis in COVID-19 Dr Swapnil Pawar Blog Written by – Dr Jose Chacko Thrombo-inflammation in COVID-19 The SARS-COV-2 virus invades endothelial cells leading to microvascular inflammation, which in turn, triggers an intense prothrombotic state, termed thrombo-inflammation. The levels of coagulation factors, including fibrinogen and factor VIII, are often elevated […]