Blood Products

Dr Swapnil Pawar April 11, 2024 8

share close
  • cover play_arrow

    Blood Products
    Dr Swapnil Pawar

Blood Products

Written by Dr Andrew Lam

Blood Products and Haemorrhagic Shock



Isolated from whole blood through centrifuge


Transfusion should be individual based. But generally:

  1.  Hb <70
  2. Concurrent cardiovascular disease + Hb <80



Contains all coagulation factors – primarily 2, 7, 9 and 10

Dose: 15ml/kg


Indicated in:

  • Bleeding with associated factor deficiencies
  • Warfarin reversal  
  • DIC



Separated from whole blood – often pooled from multiple blood donations


Transfuse if:

PLT < 10
PLT < 20 with risk factors
PLT < 50 for most surgical procedures or acutely bleeding
PLT < 100 for neurosurgical procedure



Derived from plasma – contains concentrated amount of von-willebrand factor, fibrinogen and Factors 8 and 11


Usually used in patients with fibrinogen or VWf deficiencies

Generally aim for fibrinogen > 1 at least


Massive Transfusion

Defined as replacement of either:

  • Full blood volume in 24 hours
  • >50% of blood volume in 4 hours


Each facility will have their own protocol for massive transfusion, but contains varying combinations of PRBC’s, FFP, platelets and Cryoprecipitate


Consequences of massive transfusion can include:

  • Fluid overload 
  • Hypothermia
  • Hyperkalemia
  • Lactic acidosis 
  • Hypocalcemia
Rate it
Previous episode
Thromboprophylaxis in COVID-19
Medspresso Podcast
share playlist_add
  • 16


DVT Prophylaxis

Dr Swapnil Pawar March 11, 2024

play_arrow DVT Prophylaxis Dr Swapnil Pawar VTE Prophylaxis Written by Dr Ashly Liu Venous thromboembolism risk As a junior medical officer, one of your responsibilities is to ensure all your […]

Read more trending_flat

Similar posts